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11 vitamin b6 is used to prevent isoniazid-induced b6 deficiency and neuropathy in people with a risk factor, such as pregnancy, lactation, hiv infection, alcoholism, diabetes, kidney failure, or malnutrition.

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the minor criteria are fever safe 300mg isoniazid, arthralgias,and inflammation, as demonstrated by an elevated esr.

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if an unknown amount of dom-isoniazid is ingested, consider an initial dose of 5 grams of pyridoxine given over 30 to 60 minutes in adults, or 80 mg kg of pyridoxine in children.

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monitor serum cyclosporine concentrations carefully if isoniazid is used concomitantly and upon discontinuation.

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since myambutol-inh isoniazid is known to cross the placental barrier, neonates of myambutol-inh isoniazid treated mothers should be carefully observed for any evidence of adverse affects.

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however, the use of isoniazid is recommended for those with the additional risk factors listed above 1-6 and on an individual basis in situations where there is likelihood of serious consequences to contacts who may become infected.

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