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Cyp2d6 inhibitors drugs that inhibit cyp2d6 such as quinidine, fluoxetine, paroxetine, and propafenone are likely to increase metoprolol concentration see clinical pharmacology 12.

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Food and drug administration approved low-dose paroxetine for the treatment of moderate-to-severe vasomotor symptoms such as hot flashes and night sweats associated with menopause.

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Based on the mechanism of action of snris and ssris, including paroxetine hydrochloride, and the potential for serotonin syndrome, caution is advised when paroxetine hydrochloride controlled-release tablets are coadministered with other drugs that may affect the serotonergic neurotransmitter systems, such as triptans, linezolid an antibiotic which is a reversible non-selective maoi , lithium, tramadol, or st.

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Depends some people, for reasons that are not clear, are more sensitive to changes in serotonergic medications such as paroxetine paxil and suffer from discontinuation symptoms.

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in a study where immediate-release paroxetine 30 mg once daily was dosed orally for 4 weeks, steady-state plasma concentrations of paroxetine were increased by approximately 50 during coadministration with oral cimetidine 300 mg three times daily for the final week.

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