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If severe heart block occurs, metoprolol should be discontinued and measures to increase heart rate should be employed.

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A 200 mg dose of metoprolol succinate extended-release produced a larger effect on suppression of exercise-induced and holter-monitored heart rate over 24 hours compared to 50 mg t.

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Thyrotoxicosis metoprolol effects may mask certain clinical signs of hyperthyroidism such as tachycardia.

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after 9 weeks, toprol-xl alone decreased sitting blood pressure by 6- 8 4-7 mmhg placebo-corrected change from baseline at 24 hours post-dose.

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