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In addition to a stable dose of metformin, pioglitazone, glimepiride, or glimepiride and metformin, patients whose diabetes was not adequately controlled were given either januvia 100 mg daily or placebo.

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thiazolidinediones single-dose pharmacokinetics of rosiglitazone was not meaningfully altered in subjects receiving multiple daily doses of sitagliptin, indicating that januvia is not an inhibitor of cyp2c8-mediated metabolism.

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no one knows if januvia causes pancreatic cancer , but evidence of a potential risk has been growing for years.
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