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Potassium depletion due to acetazolamide, loop diuretics and thiazide diuretics potentiates the effects of digoxin on the myocardium and may also have a small effect on reducing the renal tubular secretion of digoxin.

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Inhibition of p-gp in the intestinal cell wall may lead to increased oral absorption and decreased renal and non-renal clearance of digoxin.

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